Evidence that genetic predictors of cardiovascular diseases also increase psoriasis risk

Our recent study explores the link between genetic predictors of cardiovascular diseases and their connection to psoriasis, a chronic skin condition. Cardiovascular diseases, such as coronary heart disease and stroke, are leading causes of death worldwide. Psoriasis impacts the quality of life significantly due to its symptoms, visual appearance and chronic nature. Understanding how these conditions are connected can help in the development of better prevention and treatment strategies.

To study this connection, we analysed genetic predictors of both cardiovascular diseases and psoriasis. Genetic predictors are genetic tests used to predict a person’s genetic risk, which may increase the individual’s susceptibility to a certain disease in the future. By studying these genetic predictors, we can understand more about disease risk and their causes. We used a research method called Mendelian Randomization that helps us understand whether one condition might cause another, based on genetics.

In our study, we analysed genetic predictors from over three million people. We found that genetic predictors of heart disease and stroke also significantly increase the risk of developing psoriasis. Interestingly, we found no evidence of the opposite: genetic predictors of psoriasis also altering the risk of heart disease and stroke. Our findings question the traditional belief that psoriasis can lead to an increased risk of cardiovascular diseases. Instead, we found that the genetic predictors that elevate the risk for cardiovascular diseases can also predispose individuals to psoriasis. This suggests that there are shared biological pathways influencing both conditions.

Understanding these shared pathways is crucial. It can provide new insights into the treatment and prevention of both cardiovascular diseases and psoriasis. It also highlights the importance of monitoring cardiovascular health in individuals with psoriasis and considering early interventions to manage their overall health better. By shedding light on these genetic connections, we hope to pave the way for innovative therapeutic approaches that address both cardiovascular health and skin conditions, ultimately helping people live healthier lives.